There is a lot of papers now a days presenting energy deficits as a mainly mecahanism in Alzheimer's Disease.
In these pathway our GSK3 always is present.
One of this papers is Tau Phosphorylation by GSK3 in Different Conditions, wroten by Jesús Avila et al,  in International Journal of Alzheimer’s Disease Volume 2012.
Evere day I have a huge surprise about this enzyme.