Glycogen Synthase Kinase-3 (GSK-3)–Targeted Therapy and Imaging
Mukesh K. Pandey and Timothy R. DeGrado
Theranostics 2016, Vol. 6, Issue 4
In a 2016 review about GSK-3 inhibitors, Pandey and DeGrado showed the enzime imaging studies, with the designe of inhibitor's, as a powerful instrument to study inhibitors that can selectively target
individual pathways and differentiate between the phosphorylated and non-phosphorylated forms of
GSK-3. These studies ca evaluate drugs candidates based on noninvasive imaging measurements
of the target-to-background ratios.
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